Topic 2.4: proteins
In the Basics of Biochemistry unit students are introduced to the major classes of biologically important molecules and the types of reactions used to build and break apart those molecules. The structure and function of water, as the medium of life, is also a focus. The unit is planned to take 8 school days.
- Proteins have a very wide range of functions in living organisms.
Nature of science:
- Looking for patterns, trends and discrepancies—most but not all organisms assemble proteins from the same amino acids. (3.1)
2.4.U.1 Amino acids are linked together by condensation to form polypeptides.
2.4.U.2 There are 20 different amino acids in polypeptides synthesized on ribosomes.
2.4.U.3 Amino acids can be linked together in any sequence giving a huge range of possible polypeptides.
2.4.U.4 The amino acid sequence of polypeptides is coded for by genes.
2.4.U.5 A protein may consist of a single polypeptide or more than one polypeptide linked together.
2.4.U.6 The amino acid sequence determines the three-dimensional conformation of a protein.
2.4.U.7 Living organisms synthesize many different proteins with a wide range of functions.
2.4.U.8 Every individual has a unique proteome.
2.4.A.1 Rubisco, insulin, immunoglobulins, rhodopsin, collagen and spider silk as examples of the range of protein functions.
2.4.A.1 Denaturation of proteins by heat or by deviation of pH from the optimum.
2.4.S.1 Drawing molecular diagrams to show the formation of a peptide bond.
Modeling Protein Lab
Protein Denaturation Lab
The Macromolecules of Life
Protein Denature McGraw Hill
Amino Acid and Peptide Bond Animation
Life Cycle of a Protein
Heat Changes a Protein Structure
Amino acids and proteins from John Kyrk
Life Cycle of a Protein from Sumanas
Making polypeptides from John Kyrk
Protein Structures and Protein Folding by John Gianni
In the News:
- Development of some techniques benefits particular human populations more than others. For example, the development of lactose-free milk available in Europe and North America would have greater benefit in Africa/ Asia where lactose intolerance is more prevalent. The development of techniques requires financial investment. Should knowledge be shared when techniques developed in one part of the world are more applicable in another?
Alex Lee discusses Topic 2.4
Paul Andersen explains the structure and importance of proteins. He describes how proteins are created from amino acids connected by dehydration synthesis. He shows the importance of chemical properties in the R-groups of individual amino acids in the polypeptide. He explains the four levels of protein folding and gives you an opportunity to fold proteins of your own using the game Foldi
Professor Dave explains how everyone has heard of proteins. What are they on the molecular level? They're polymers of amino acids, of course. They make up most of your body, so we have to understand their structure very well! Check this out to learn the hierarchy of protein structure so that we can later learn all about what different types of proteins can do.