Topic 8.1: Metabolism
- Metabolic reactions are regulated in response to the cell’s needs.
Nature of science:
- Developments in scientific research follow improvements in computing—developments in bioinformatics, such as the interrogation of databases, have facilitated research into metabolic pathways. (3.8)
8.1 U 1 Metabolic pathways consist of chains and cycles of enzyme-catalysed reactions.
8.1 U 2 Enzymes lower the activation energy of the chemical reactions that they catalyse.
8.1 U 3 Enzyme inhibitors can be competitive or non-competitive.
8.1.U 4 Metabolic pathways can be controlled by end-product inhibition.
8.1 A 1 End-product inhibition of the pathway that converts threonine to isoleucine.
8.1 A 2 Use of databases to identify potential new anti-malarial drugs.
8.1 S 1 Calculating and plotting rates of reaction from raw experimental results.
8.1 S 2 Distinguishing different types of inhibition from graphs at specified substrate concentration.
In The News
In The News
- Many metabolic pathways have been described following a series of carefully controlled and repeated experiments. To what degree can looking at component parts give us knowledge of the whole?
Alex Lee discusses Topic 8.1