Topic 11.1 Antibody Production and Vaccination
- Immunity is based on recognition of self and destruction of foreign material.
Nature of science:
- Consider ethical implications of research—Jenner tested his vaccine for smallpox on a child. (4.5)
11.1 U 1 Every organism has unique molecules on the surface of its cells.
11.1 U 2 Pathogens can be species-specific although others can cross species barriers.
11.1 U 3 B lymphocytes are activated by T lymphocytes in mammals.
11.1 U 4 Activated B cells multiply to form clones of plasma cells and memory cells.
11.1 U 5 Plasma cells secrete antibodies.
11.1 U 6 Antibodies aid the destruction of pathogens.
11.1 U 7 White cells release histamine in response to allergens.
11.1 U 8 Histamines cause allergic symptoms.
11.1 U 9 Immunity depends upon the persistence of memory cells.
11.1. U 10 Vaccines contain antigens that trigger immunity but do not cause the disease.
11.1 U 11 Fusion of a tumour cell with an antibody-producing plasma cell creates a hybridoma cell.
11.1. U 12 Monoclonal antibodies are produced by hybridoma cells.
11.1 A 1 Smallpox was the first infectious disease of humans to have been eradicated by vaccination
11.1 A 2 Monoclonal antibodies to HCG are used in pregnancy test kits.
11.1 A 3 Antigens on the surface of red blood cells stimulate antibody production in a person with a different blood group
11.1 S 1 Analysis of epidemiological data related to vaccination programmes.
In the News
In the News
- The World Health Organization initiated the campaign for the global eradication of smallpox in 1967. The campaign was deemed a success in 1977, only 10 years later.
Alex Lee discusses Topic 11.1